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Even if fertilization occurs, the presence of fragmented DNA increases the likelihood of poor reproductive outcomes, including failed implantation, miscarriage, and the development of genetic abnormalities in the offspring

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1 Specifically, two non-cleavable linkers, three acid-cleavable linkers, eight enzyme-cleavable linkers, and three contain GSH-cleavable linkers appeared in the fourteen approved ADCs (the linkers in Mylotarg and Besponsa are both acid-cleavable and GSH-cleavable, Table 1)

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