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A., Universidad Veracruzana, Mexico Updates Copyright 2025 Felicianna, Cheung, Lo, Zhang, Leung, Ismaiah, Rosa-Sibakov, Iannone, Gmez-Gallego, Kolehmainen, Rischer, Nordlund and El-Nezami

Early changes include synaptic loss, dendritic spine retraction, mitochondrial fragmentation, and alterations in gene expression, all of which contribute to neuronal dysfunction before irreversible cell death [39, 41, 43]

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Used for reconstituting lyophilized in laboratory settings

There is evidence that higher oxidative burden correlates with more circadian rhythm disruption in older organisms, creating a vicious cycle