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Key Points Semaglutide redefining diabetes and obesity treatment 2026: inflection point with patent expiries Manufacturing scalability remains a key constraint Generic entry limited by technical and regulatory barriers Next-generation therapies driving competitive pressure Executive Summary Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), led by semaglutide, have fundamentally transformed the global management of type 2 diabetes mellitus and obesity, delivering substantial improvements in glycemic control, sustained weight reduction, and cardiovascular risk mitigation

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